Lab test
RPR Test (Syphilis) – Rapid Plasma Reagin
RPR Test (Syphilis) – Rapid Plasma Reagin can be ordered without a referral, and this guide covers what to expect. The RPR test screens for syphilis by looking for antibodies in your blood that your body makes in response to the infection.
What this test is
This is a common screening test used to detect the presence of syphilis, a sexually transmitted infection. It detects antibodies produced by your immune system when exposed to the bacteria that causes syphilis.
What it measures
- Syphilis Antibodies — indicates the body's immune response to syphilis bacteria
What the test involves
A healthcare professional will collect a blood sample, typically from a vein in your arm. The sample is then sent to a laboratory for analysis.
Why it is often ordered
A clinician may order this test if they suspect you have syphilis based on symptoms or potential exposure. It is also sometimes used as part of routine screening.
Preparation
No special preparation is usually needed for this test. Always follow the specific instructions provided by the laboratory where you will have your blood drawn.
How results are reported
Results are typically reported as reactive, non-reactive, or borderline. A reactive result suggests the possible presence of syphilis and may require further confirmatory testing. Reference ranges can vary between laboratories.
Before you go
- Turnaround time
- Fasting requirements
- Specific preparation instructions
FAQ
Frequently asked questions
What does a reactive RPR result mean?
A reactive result means that substances that can be associated with syphilis were detected in your blood. It does not definitively confirm a syphilis infection and usually requires additional, more specific tests to confirm the diagnosis.
Can RPR test results be non-reactive if I have syphilis?
In some early stages of syphilis, or in certain individuals, the RPR test might be non-reactive. If there is a strong suspicion of syphilis despite a non-reactive RPR, your clinician may order other tests.
How is syphilis treated?
Syphilis is typically treated with antibiotics, most commonly penicillin. The specific treatment plan and duration depend on the stage of the infection and other individual factors. It is important to complete the full course of treatment prescribed by your doctor.
Can other conditions cause a reactive RPR test?
Yes, certain other conditions, such as some viral infections, autoimmune diseases, or even recent vaccinations, can sometimes cause a false-positive RPR result. This is why confirmatory testing is often necessary.
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